COVID-19 has drastically impacted the healthcare system across the continuum of care. View the resources below, submitted by healthcare providers who are managing COVID-19 patients, to help you and your organization get ahead of the COVID-19 pandemic.

Have a resource to share with other healthcare providers? Please submit it via email to info@sepsisinstitute.org.

Webinars

Register for upcoming live events or view recordings from past webinars on COVID-19.

COVID-19 and Sepsis (Recorded 3/25/20)
COVID-19, Sepsis, and Home Health Care (Recorded 4/23/20)
Mobilizing Telehealth During the COVID-19 Pandemic (Recorded 5/5/20)
COVID-19: Current Treatment Guidelines for the Critically Ill (Recorded 5/28/20)
Surviving COVID-19: The Path to Optimal Recovery (7/9/20)
COVID-19 + Sepsis Management: How They Are Linked and What We Are Learning (10/28/20)
Antimicrobial Resistance in the Time of COVID-19 (11/12/20) 
Sepsis in the Time of COVID-19: Perspectives From Front-line Sepsis Coordinators (2/25/21)
Live Webinar: COVID-19 in Pregnancy: Best Practices for Management of the Maternal Population (5/13/21)

Forum Discussion

Join the Sepsis Alliance Clinical Community to take part in a discussion with your peers (healthcare providers) about COVID-19.

Medical Journal Articles

Mask adherence and rate of COVID-19 across the United States April 14, 2021 PLOS ONE
Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients April 13, 2021 British Journal of Sports Medicine 
Cases of Cerebral Venous Sinus Thrombosis with Thrombocytopenia after Receipt of the Johnson & Johnson COVID-19 Vaccine April 13, 2021 CDC 
Emergency Department Visits for COVID-19 by Race and Ethnicity — 13 States, October–December 2020 April 12, 2021 CDC 
Trends in Racial and Ethnic Disparities in COVID-19 Hospitalizations, by Region — United States, March–December 2020 April 12, 2021 
Mortality Among US Patients Hospitalized With SARS-CoV-2 Infection in 2020 April 8, 2021 JAMA 
Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers April 7, 2021 JAMA 
Association of Human Mobility Restrictions and Race/Ethnicity–Based, Sex-Based, and Income-Based Factors with Inequities in Well-being During the COVID-19 Pandemic in the United States April 7, 2021 JAMA 
Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians April 6, 2021 Annals of Internal Medicine 
Trends in Geographic and Temporal Distribution of US Children With Multisystem Inflammatory Syndrome During the COVID-19 Pandemic April 6, 2021 JAMA Pediatrics 
6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records April 6, 2021 THE LANCET 
Greater Frequency of Stroke in Men With COVID-19 and High Comorbidity Burden April 6, 2021 Neurology Advisor 
Association of Sociodemographic Factors and Blood Group Type With Risk of COVID-19 in a US Population April 5, 2021 JAMA 
Incidence of 30-Day Venous Thromboembolism in Adults Tested for SARS-CoV-2 Infection in an Integrated Health Care System in Northern California April 5, 2021 JAMA 
Excess Deaths From COVID-19 and Other Causes in the US, March 1, 2020, to January 2, 2021 April 2, 2021 JAMA 
Counties with High COVID-19 Incidence and Relatively Large Racial and Ethnic Minority Populations — United States, April 1–December 22, 2020 April 2, 2021 CDC 
The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients April 1, 2021 Critical Care Medicine 
Use of Biomarkers to Identify Acute Kidney Injury to Help Detect Sepsis in Patients With Infection April 1, 2021 Critical Care Medicine 
Aspirin Use Is Associated with Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients with Coronavirus Disease 2019 April 2021 Anesthesia & Analgesia 
COVID-19 illness in relation to sleep and burnout March 22, 2021 BMJ Nutrition, Prevention, & Health 
Transmissibility and transmission of respiratory viruses March 22, 2021 Nature 
Outcomes and Risk Factors Associated With SARS-CoV-2 Infection in a North American Registry of Patients With Multiple Sclerosis March 19, 2021 JAMA 
Inequities in Technology Contribute to Disparities in COVID-19 Vaccine Distribution March 19, 2021 
US Hospital Capacity Managers’ Experiences and Concerns Regarding Preparedness for Seasonal Influenza and Influenza-like Illness March 19, 2021 JAMA 
Assessment of the Appropriateness of Antimicrobial Use in US Hospitals March 18, 2021 JAMA 
Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality Among Patients With COVID-19 Admitted to the Intensive Care Unit The INSPIRATION Randomized Clinical Trial March 18, 2021 JAMA 
Outcomes for Patients Following Hospitalization for COVID-19 March 17, 2021 JAMA 
Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study March 17, 2021 The Lancet 
Immunogenicity of a Single Dose of SARS-CoV-2 Messenger RNA Vaccine in Solid Organ Transplant Recipients March 15, 2021 JAMA 
Experiences of Latinx Individuals Hospitalized for COVID-19 A Qualitative Study March 11, 2021 JAMA
Risk Factors Associated With SARS-CoV-2 Seropositivity Among US Health Care Personnel March 10, 2021 JAMA 
The Devastating Impact of Covid-19 on Individuals with Intellectual Disabilities in the United States March 5, 2021 NEJM Catalyst 
Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome March 5, 2021 JAMA 
Intestinal host response to SARS-CoV-2 infection and COVID-19 outcomes in patients with gastrointestinal symptoms March 4, 2021 Gastroenterology 
Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19 March 4, 2021 
Acute kidney injury in pediatric patients hospitalized with acute COVID-19 and Multisystem Inflammatory Syndrome in Children associated with COVID-19 March 3, 2021 Kidney International 
Coronavirus Disease 2019 Hospitalizations Attributable to Cardiometabolic Conditions in the United States: A Comparative Risk Assessment Analysis February 25, 2021 Journal of the American Heart Association 
Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection February 24, 2021 JAMA 
Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19 February 24, 2021 JAMA 
BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting February 24, 2021 The New England Journal of Medicine 
The COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of the Bamlanivimab Plus Etesevimab Combination for the Treatment of COVID-19 Last Updated: February 23, 2021 NIH COVID-19 Treatment Guidelines 
Impact of the Influenza Vaccine on COVID-19 Infection Rates and Severity February 22, 2021 American Journal of Infection Control 
Sequelae in Adults at 6 Months After COVID-19 Infection February 19, 2021 JAMA
Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 February 17, 2021 JAMA 
Thresholds of Glycemia and the Outcomes of COVID-19 Complicated With Diabetes: A Retrospective Exploratory Study Using Continuous Glucose Monitoring February 11, 2021 Diabetes Care 
Asthma and risk of infection, hospitalisation, ICU admission and mortality from COVID-19: Systematic review and meta-analysis February 5, 2021 Journal of Asthma
Bacterial superinfections among persons with coronavirus disease 2019:A comprehensive review of data from postmortem studies February 4, 2021 Open Forum Infectious Diseases 
Clinical Course of Cancer Patients With COVID-19: A Retrospective Cohort Study November 2, 2020/February 2021 JNCI Cancer Spectrum 
Geographic Variation in Racial Disparities in Mortality from Influenza and Pneumonia in the US in the Pre-COVID-19 Era January 1, 2021 CHEST 
Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection February 12, 2021 JAMA 
Recommended Adult Immunization Schedule, United States, 2021* February 11, 2021 Annals of Internal Medicine 
COVID Clot Prevention: Hit It Early - Observational study supports guidelines February 11, 2021 Infectious Disease 
Translating Post-Sepsis Care to Post-COVID Care: The Case for a Virtual Recovery Program February 10, 2021 Annals of the American Thoracic Society 
Factors Associated With Racial Differences in Deaths Among Nursing Home Residents With COVID-19 Infection in the US February 10, 2021 JAMA 
Characteristics and outcomes of hospital admissions for COVID-19 and influenza in the Toronto area February 10, 2021 CMAJ (Canadian Medical Association Journal) 
Coronavirus (COVID-19) Update: FDA Authorizes Monoclonal Antibodies for Treatment of COVID-19 February 9, 2021 FDA 
COVID‐19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US February 9, 2021 Alzheimer’s & Dementia
COVID-19 Guidelines updated January 29, 2021 Surviving Sepsis Campaign
Association of Social and Demographic Factors With COVID-19 Incidence and Death Rates in the US January 29, 2021 JAMA
Disease Severity, Pregnancy Outcomes and Maternal Deaths among Pregnant Patients with SARS-CoV-2 Infection in Washington State January 26, 2021 American Journal of Obstetrics & Gynecology
Association of Smoking and Cumulative Pack-Year Exposure With COVID-19 Outcomes in the Cleveland Clinic COVID-19 Registry January 25, 2021 JAMA
Full-dose blood thinners decreased need for life support and improved outcome in hospitalized COVID-19 patients January 22, 2021 NIH
Rates of COVID-19-Related Outcomes in Cancer Compared with Non-Cancer Patients January 21 JNCI Cancer Spectrum
Association of Social and Economic Inequality With Coronavirus Disease 2019 Incidence and Mortality Across US Counties January 20, 2021 JAMA
Association of Intensive Care Unit Patient Load and Demand With Mortality Rates in US Department of Veterans Affairs Hospitals During the COVID-19 Pandemic January 19, 2021 JAMA
Mask-wearing and control of SARS-CoV-2 transmission in the USA: a cross-sectional study January 19, 2021 The Lancet
Emergence of SARS-CoV-2 B.1.1.7 Lineage — United States, December 29, 2020–January 12, 2021 January 15, 2021 CDC
Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine January 13, 2021 The New England Journal of Medicine
International Impact of COVID-19 on the Diagnosis of Heart Disease January 2021 Journal of the American College of Cardiology
Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19 January 11, 2021 
Genetic Variants of SARS-CoV-2 May Lead to False Negative Results with Molecular Tests for Detection of SARS-CoV-2 - Letter to Clinical Laboratory Staff and Health Care Providers January 8, 2021 FDA
Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study January 8, 2021 The Lancet
Assessment of Day-7 Postexposure Testing of Asymptomatic Contacts of COVID-19 Patients to Evaluate Early Release from Quarantine — Vermont, May–November 2020 January 8, 2021 CDC
SARS-CoV-2 Transmission From People Without COVID-19 Symptoms January 7, 2021 JAMA
Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 - Preliminary report January 7, 2021 MedRxiv
Comparison of Out-of-Hospital Cardiac Arrests and Fatalities in the Metro Detroit Area During the COVID-19 Pandemic With Previous-Year Events January 6, 2021 JAMA
Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults January 6, 2021 The New England Journal of Medicine
Impact of COVID‐19 on inpatient referral of acute heart failure: a single‐centre experience from the south‐west of the UK January 6 ESC Heart Failure
Persistent Poor Health Post-COVID-19 Is Not Associated with Respiratory Complications or Initial Disease Severity January 6, 2021 Annals of the American Thoracic Society
Umbilical cord mesenchymal stem cells for COVID‐19 acute respiratory distress syndrome: A double‐blind, phase 1/2a, randomized controlled trial January 5, 2021 Stem Cells Translational Medicine
Estimation of US SARS-CoV-2 Infections, Symptomatic Infections, Hospitalizations, and Deaths Using Seroprevalence Surveys January 5, 2021 JAMA
Risk Factors Associated With All-Cause 30-Day Mortality in Nursing Home Residents With COVID-19 January 4, 2021 JAMA

Guideline Documents

Review guidance from countries and hospital systems that are responding to COVID-19.

NIH COVID-19 Treatment Guidelines - Last updated February 11, 2021
Surviving Sepsis Campaign COVID-19 Guidelines- Last updated January 29, 2021
Brigham and Women's Hospital COVID-19 Clinical Guidelines
Massachusetts General Hospital Department of Medicine COVID-19 Treatment Guidelines
Michigan Medicine University of Michigan COVID-19 Information and Guidelines
Nebraska Medicine COVID-19 Resources for Providers
Penn Medicine Treatment Guidelines for SARS-CoV-2 Infection
University of Washington UW Medicine COVID-19 Resources

Training to Help Staff Be Critical Care Capable

SCCM Critical Care for the Non-ICU Clinician Online Training
Critical Care for the Hospitalist Webinar Series
COVID-19 Back to the Basics: Caring for the Critically Ill Video Series
Point-of-Care Ultrasound in COVID-19 (WVU)

Resources Pages

View additional resources from organizations and societies.

Personal Protective Equipment Preservation Best Practices FEMA
CDC COVID-19 FAQ
AAFP COVID-19 Resources for Family Physicians
AAP COVID-19 Resources for Pediatricians
ACCP COVID-19 Resources CHEST
ACEP COVID-19 Resources for Emergency Physicians
ACOG COVID-19 Resources for OB/GYN
ACP COVID-19 Physician's Guide for Internists
ACS COVID-19 Resources for Surgeons and Trauma Centers
IDSA COVID-19 Resources Infectious Disease
SCCM COVID-19 Emergency Resources for Critical Care
SHM COVID-19 Resources for Hospitalists
AAPA COVID-19 Resources for Physicians' Assistants
AANA COVID-19 Resources for Nurse Anesthetists
AANP COVID-19 Recommendations for Nurse Practitioners
ANA COVID-19 Resources for Nurses
AACN COVID-19 Resources for Critical Care Nurses
APTA COVID-19 Resources for Physical Therapists
NAHC COVID-19 Resources for Home Care & Hospice
American College of Allergy, Asthma & Immunology COVID-19 Resources