Sponsored by Baxter: Chasing FRESH Dreams: The Promise of Dynamic Measures of Fluid Responsiveness to Optimize Sepsis Resuscitation

Session Description: 

Fluid resuscitation is a cornerstone of contemporary sepsis management. Fluids are prescribed to improve oxygen delivery through transient increases in cardiac output, thus helping to mitigate further end organ damage. However, the optimal timing and dose of fluid resuscitation has been unclear. Clinicians may risk overestimating how much fluid to administer. If no objective gauge of fluid need is used during resuscitation, only about 50% of the fluids administered to patients will improve cardiac output. Excessive fluid administration is associated with impaired organ function and worse outcomes, including death. The use of dynamic assessment of fluid responsiveness such as passive leg raise is a reproducible, robust, validated approach to gauge benefit from fluid resuscitation. This talk will summarize the current state of fluid resuscitation and discuss a recent randomized trial that suggests improved patient outcomes in severe sepsis and septic shock patients when using the passive leg raise coupled with an objective measurement of stroke volume. 

This session was originally presented in September 2021 as part of the 2021 Sepsis Alliance Summit.

Target Audience

Nurses, Advanced Practice Providers, Physicians, Emergency Responders, Pharmacists, Medical Technologists, Respiratory Therapists, Physical/ Occupational Therapist, Social Workers, Mental Health Professionals, Students, IT Professionals, Sepsis Survivors, Advocates, and more! 


Sepsis Alliance gratefully acknowledges the support provided for this session by Baxter.


Course summary
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Andre L. Holder, MD, MSc

Assistant Professor, Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, Emory University School of Medicine

 Dr. Holder is an NIH-funded clinician scientist with board certification in emergency medicine, internal medicine and critical care medicine. He is an assistant professor in the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine at Emory University. His primary area of research focus is the appropriate timing and use of interventions to prevent or mitigate syndromes of critical illness (e.g. sepsis) by forecasting the evolution of patient decompensation and organ failure. Through collaborations with colleagues in Emory’s Department of Biomedical Informatics, he creates and tests data-driven, machine learning algorithms to predict clinical decompensation from sepsis. Other areas of research interest include early sepsis resuscitation and hemodynamic monitoring, cardiopulmonary resuscitation, & novel sepsis biomarkers. He is a practicing intensivist in the medical ICU at Grady Memorial Hospital and the medical/surgical ICU at Emory Midtown Hospital, both in Atlanta, GA. 

No continuing education credits are offered for this session.

Medical Disclaimer

The information on or available through this site is intended for educational purposes only. Sepsis Alliance does not represent or guarantee that information on or available through this site is applicable to any specific patient’s care or treatment. The educational content on or available through this site does not constitute medical advice from a physician and is not to be used as a substitute for treatment or advice from a practicing physician or other healthcare provider. Sepsis Alliance recommends users consult their physician or healthcare provider regarding any questions about whether the information on or available through this site might apply to their individual treatment or care.

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This activity includes:

  • Slides to download
  • Pre-recorded presentation